9J2Z

mouse cGAS catalytic domain bound with RU.521

This is a non-PDB format compatible entry.

Summary for 9J2Z

• Entry DOI: 10.2210/pdb9j2z/pdb
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, (4~{S},5~{R})-2-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-5-methyl-4-[(1~{S})-3-oxidanylidene-1~{H}-2-benzofuran-1-yl]pyrazolidin-3-one (3 entities in total)
• Functional Keywords: cgas, inhibitor, immune system
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 171561.85

Authors

Zhao, W.F.,Li, M.J.,Xu, Y.C. (deposition date: 2024-08-07, release date: 2025-06-04)

• Primary citation: Zhao, W.F.,Xu, Y.C.; Discovery of novel cGAS inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.39 Å)