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9J2Z

mouse cGAS catalytic domain bound with RU.521

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Cyclic GMP-AMP synthasepolymer36242512.14UniProt (Q8C6L5)
Pfam (PF03281)
Pfam (PF20266)
Mus musculus (house mouse)cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2E, G, I, K
(A, B, C, D)
ZINC IONnon-polymer65.44Chemie (ZN)
3F, H, J
(B, C, D)
(4~{S},5~{R})-2-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-5-methyl-4-[(1~{S})-3-oxidanylidene-1~{H}-2-benzofuran-1-yl]pyrazolidin-3-onenon-polymer417.23Chemie (A1EAM)
Sequence modifications
A, B, C, D: 146 - 507 (UniProt: Q8C6L5)
PDBExternal DatabaseDetails
Ser 146Glu 146conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight170048.5
Non-Polymers*Number of molecules7
Total formula weight1513.4
All*Total formula weight171561.9
*Water molecules are not included.

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PDB entries from 2025-06-18

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