Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9J2Z

mouse cGAS catalytic domain bound with RU.521

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:23647843

Chain	Residue	Details
A	THR197
B	SER199
B	GLU211
B	ASP213
B	ASP307
B	GLU371
B	LYS402
B	SER420
C	THR197
C	SER199
C	GLU211
A	SER199
C	ASP213
C	ASP307
C	GLU371
C	LYS402
C	SER420
D	THR197
D	SER199
D	GLU211
D	ASP213
D	ASP307
A	GLU211
D	GLU371
D	LYS402
D	SER420
A	ASP213
A	ASP307
A	GLU371
A	LYS402
A	SER420
B	THR197

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:24332030, ECO:0007744\|PDB:4LEZ

Chain	Residue	Details
A	GLY290
D	GLY290
D	LYS350
D	ARG364
A	LYS350
A	ARG364
B	GLY290
B	LYS350
B	ARG364
C	GLY290
C	LYS350
C	ARG364

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:24332030, ECO:0000269\|PubMed:24462292, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0000269\|PubMed:32814054, ECO:0000269\|PubMed:32911481, ECO:0000269\|PubMed:32913000, ECO:0007744\|PDB:5N6I, ECO:0007744\|PDB:5XZB, ECO:0007744\|PDB:5XZE, ECO:0007744\|PDB:5XZG, ECO:0007744\|PDB:6X59, ECO:0007744\|PDB:7BUJ, ECO:0007744\|PDB:7BUM, ECO:0007744\|PDB:7BUQ, ECO:0007744\|PDB:7JO9, ECO:0007744\|PDB:7JOA

Chain	Residue	Details
A	HIS378
A	CYS384
B	HIS378
B	CYS384
C	HIS378
C	CYS384
D	HIS378
D	CYS384

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:24332030, ECO:0000269\|PubMed:24462292, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0000269\|PubMed:32814054, ECO:0000269\|PubMed:32911481, ECO:0000269\|PubMed:32913000, ECO:0007744\|PDB:5N6I, ECO:0007744\|PDB:5XZB, ECO:0007744\|PDB:5XZE, ECO:0007744\|PDB:5XZG, ECO:0007744\|PDB:6XJD, ECO:0007744\|PDB:7BUJ, ECO:0007744\|PDB:7BUM, ECO:0007744\|PDB:7BUQ, ECO:0007744\|PDB:7JO9, ECO:0007744\|PDB:7JOA

Chain	Residue	Details
A	CYS385
B	CYS385
C	CYS385
D	CYS385

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:24332030, ECO:0000269\|PubMed:24462292, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0000269\|PubMed:32814054, ECO:0000269\|PubMed:32911480, ECO:0000269\|PubMed:32911481, ECO:0000269\|PubMed:32913000, ECO:0007744\|PDB:5N6I, ECO:0007744\|PDB:5XZB, ECO:0007744\|PDB:5XZE, ECO:0007744\|PDB:5XZG, ECO:0007744\|PDB:6X5A, ECO:0007744\|PDB:7BUJ, ECO:0007744\|PDB:7BUM, ECO:0007744\|PDB:7BUQ, ECO:0007744\|PDB:7JO9, ECO:0007744\|PDB:7JOA

Chain	Residue	Details
A	CYS392
B	CYS392
C	CYS392
D	CYS392

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: Arginine-anchor => ECO:0000269\|PubMed:31808743, ECO:0000269\|PubMed:32911480, ECO:0000269\|PubMed:32911481, ECO:0000269\|PubMed:32913000

Chain	Residue	Details
A	ARG241
B	ARG241
C	ARG241
D	ARG241

site_id	SWS_FT_FI7
Number of Residues	4
Details	SITE: Cleavage; by CASP3 => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	ASP307
B	ASP307
C	ASP307
D	ASP307

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-lactoyllysine => ECO:0000269\|PubMed:39322678

Chain	Residue	Details
A	LYS156
B	LYS156
C	LYS156
D	LYS156

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269\|PubMed:35460603

Chain	Residue	Details
A	GLU176
B	GLU176
C	GLU176
D	GLU176

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	SER199
B	SER199
C	SER199
D	SER199

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	TYR201
B	TYR201
C	TYR201
D	TYR201

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:26829768

Chain	Residue	Details
A	GLU272
B	GLU272
C	GLU272
D	GLU272

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269\|PubMed:26440888, ECO:0000269\|PubMed:32351706

Chain	Residue	Details
A	SER291
B	SER291
C	SER291
D	SER291

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: 5-glutamyl glutamate => ECO:0000269\|PubMed:26829768

Chain	Residue	Details
A	GLU302
B	GLU302
C	GLU302
D	GLU302

site_id	SWS_FT_FI15
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	LYS372
D	LYS372
D	LYS382
D	LYS402
A	LYS382
A	LYS402
B	LYS372
B	LYS382
B	LYS402
C	LYS372
C	LYS382
C	LYS402

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:32474700

Chain	Residue	Details
A	SER420
B	SER420
C	SER420
D	SER420

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: N6-methyllysine => ECO:0000269\|PubMed:35210392

Chain	Residue	Details
A	LYS491
B	LYS491
C	LYS491
D	LYS491

site_id	SWS_FT_FI18
Number of Residues	12
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	CYS392
D	CYS392
D	CYS393
D	CYS459
A	CYS393
A	CYS459
B	CYS392
B	CYS393
B	CYS459
C	CYS392
C	CYS393
C	CYS459

site_id	SWS_FT_FI19
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269\|PubMed:27637147

Chain	Residue	Details
A	LYS217
B	LYS217
C	LYS217
D	LYS217

site_id	SWS_FT_FI20
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269\|PubMed:27637147, ECO:0000269\|PubMed:32457395

Chain	Residue	Details
A	LYS464
B	LYS464
C	LYS464
D	LYS464

site_id	SWS_FT_FI21
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:27637147, ECO:0000269\|PubMed:32457395

Chain	Residue	Details
A	LYS271
B	LYS271
C	LYS271
D	LYS271

site_id	SWS_FT_FI22
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269\|PubMed:29426904

Chain	Residue	Details
A	LYS335
B	LYS335
C	LYS335
D	LYS335

site_id	SWS_FT_FI23
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	LYS372
B	LYS372
C	LYS372
D	LYS372

site_id	SWS_FT_FI24
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269\|PubMed:28095500

Chain	Residue	Details
A	LYS382
B	LYS382
C	LYS382
D	LYS382

site_id	SWS_FT_FI25
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	LYS399
A	LYS402
B	LYS399
B	LYS402
C	LYS399
C	LYS402
D	LYS399
D	LYS402

site_id	SWS_FT_FI26
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:38418882

Chain	Residue	Details
A	LYS409
A	LYS410
B	LYS409
B	LYS410
C	LYS409
C	LYS410
D	LYS409
D	LYS410

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)