9HXV

Crystal structure of TET2-DNA in complex with IOX1

Summary for 9HXV

• Entry DOI: 10.2210/pdb9hxv/pdb
• Descriptor: Methylcytosine dioxygenase TET2, 12mer-DNA, FE (II) ION, ... (8 entities in total)
• Functional Keywords: iox1, tet2, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 59793.49

Authors

Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2025-01-08, release date: 2025-04-09)

• Primary citation: Willems, S.,Maksumic, L.,Niggenaber, J.,Lin, T.-C.,Schulz, T.,Weisner, J.,Sievers, S.,Mueller, M.-P.,Summerer, D.,Rauh, D.; Advancing TET Inhibitor Development: From Structural Insights to Biological Evaluation; Acs Med.Chem.Lett., 2025; DOI: 10.1021/acsmedchemlett.5c00042

Experimental method

X-RAY DIFFRACTION (1.9 Å)