9HXV
Crystal structure of TET2-DNA in complex with IOX1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methylcytosine dioxygenase TET2 | polymer | 467 | 51867.9 | 1 | UniProt (Q6N021) Pfam (PF12851) | Homo sapiens (human) | |
| 2 | B, C (B, C) | 12mer-DNA | polymer | 12 | 3676.4 | 2 | Homo sapiens | ||
| 3 | D (A) | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 4 | E, F, G (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | H (A) | 8-hydroxyquinoline-5-carboxylic acid | non-polymer | 189.2 | 1 | Chemie (8XQ) | |||
| 6 | I (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | J (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | K, L, M (A, B, C) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 1129 - 1828 (UniProt: Q6N021)
A: 1844 - 1936 (UniProt: Q6N021)
| PDB | External Database | Details |
|---|---|---|
| Gly 1122 | - | expression tag |
| Ser 1123 | - | expression tag |
| His 1124 | - | expression tag |
| Met 1125 | - | expression tag |
| Gly 1126 | - | expression tag |
| Gly 1127 | - | expression tag |
| Ser 1128 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1829 | - | linker |
| Gly 1830 | - | linker |
| Gly 1831 | - | linker |
| Gly 1832 | - | linker |
| Ser 1833 | - | linker |
| Gly 1834 | - | linker |
| Gly 1835 | - | linker |
| Gly 1836 | - | linker |
| Gly 1837 | - | linker |
| Ser 1838 | - | linker |
| Gly 1839 | - | linker |
| Gly 1840 | - | linker |
| Gly 1841 | - | linker |
| Gly 1842 | - | linker |
| Ser 1843 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 59220.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 572.8 | |
| All* | Total formula weight | 59793.5 |
