9HJC

Cryo-EM structure of thiamine-bound human TPK1

Summary for 9HJC

• Entry DOI: 10.2210/pdb9hjc/pdb
• EMDB information: 52212
• Descriptor: Thiamine pyrophosphokinase 1, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, MAGNESIUM ION (3 entities in total)
• Functional Keywords: thiamine, kinase, thiamine metabolism dysfunction syndrome 5, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 62762.02

Authors

Gabriel, F.,Loew, C. (deposition date: 2024-11-28, release date: 2025-03-12, Last modification date: 2025-07-09)

• Primary citation: Gabriel, F.; Structural Basis of Membrane Transport and Pyrophosphorylation of Thiamine in Humans; Thesis, 2024

Experimental method

ELECTRON MICROSCOPY (2.1 Å)