9H4V

Crystal structure of the adduct formed upon reaction of aurothiomalate with human serum transferrin (apo-form)

Summary for 9H4V

• Entry DOI: 10.2210/pdb9h4v/pdb
• Descriptor: Serotransferrin, CITRIC ACID, GOLD ION, ... (5 entities in total)
• Functional Keywords: myochrysine, metallodrug, gold-based drugs, protein metalation, human transferrin, aurothiomalate, metal transport
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 156069.53

Authors

Troisi, R.,Galardo, F.,Messori, L.,Sica, F.,Merlino, A. (deposition date: 2024-10-21, release date: 2025-02-12, Last modification date: 2025-04-09)

• Primary citation: Troisi, R.,Galardo, F.,Messori, L.,Sica, F.,Merlino, A.; The X-ray structure of the adduct formed upon reaction of aurothiomalate with apo-transferrin: gold binding sites and a unique transferrin structure along the apo/holo transition pathway; Inorg Chem Front, 12:2627-2637, 2025; DOI: 10.1039/D4QI03184A

Experimental method

X-RAY DIFFRACTION (3.02 Å)