Summary for 9H33
| Entry DOI | 10.2210/pdb9h33/pdb |
| Related | 9H30 9H31 9H32 |
| Descriptor | Tubulin alpha-1B chain, GLYCEROL, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 5-{1-[6-({(4R)-2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,4-dihydro-1H-isoindol-4-yl}amino)-6-oxohexyl]-1H-1,2,3-triazol-4-yl}pentanoate, ... (13 entities in total) |
| Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
| Biological source | Rattus norvegicus (Norway rat) More |
| Total number of polymer chains | 6 |
| Total formula weight | 265653.02 |
| Authors | Maiocchi, A.,Abel, A.-C.,Boiarska, Z.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (deposition date: 2024-10-15, release date: 2025-10-29) |
| Primary citation | Maiocchi, A.,Abel, A.-C.,Basellini, M.,Perez Pena, H.,Boiarska, Z.,Ferrandi, E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Prota, A.E.,Passarella, D. Effective tubulin degradation by rationally designed Proteolysis Targeting Chimeras To Be Published, |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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