9H31

T2R-TTL-PROTAC4 complex

This is a non-PDB format compatible entry.

Summary for 9H31

• Entry DOI: 10.2210/pdb9h31/pdb
• Related: 9H30
• Descriptor: Tubulin alpha-1B chain, N-[5-(1-{2-[4-({[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}carbonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)pentanoyl]-3-methyl-D-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265823.29

Authors

Maiocchi, A.,Abel, A.-C.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (deposition date: 2024-10-15, release date: 2025-10-29, Last modification date: 2026-05-13)

• Primary citation: Maiocchi, A.,Abel, A.C.,Basellini, M.,Perez-Pena, H.,Boiarska, Z.,Ferrandi, E.E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Passarella, D.,Prota, A.E.; Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras; Biorxiv, 2025; DOI: 10.1101/2025.05.22.655572

Experimental method

X-RAY DIFFRACTION (2.2 Å)