9H31

T2R-TTL-PROTAC4 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	451	50204.4	2	UniProt (P81947)	Bos taurus (domestic cattle)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (Q6B856)	Bos taurus (domestic cattle)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63043)	Rattus norvegicus (Norway rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin--tyrosine ligase	polymer	384	44378.5	1		Gallus gallus (chicken)
5	G, N (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, K, O, R, V (A, B, C, D, F)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
7	I, L, P, T (A, B, C, E)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
8	J, Q (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
9	M (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
10	S (D)	N-[5-(1-{2-[4-({[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}carbonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)pentanoyl]-3-methyl-D-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide	non-polymer		1276.9	1	Chemie (A1ISE)
11	U (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
12	AA, BA, W, X, Y... (E, F, A, B, C...)	water	water		18.0	388	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261631.3
Non-Polymers*	Number of molecules	16
	Total formula weight	4192.0
All*	Total formula weight	265823.3

*Water molecules are not included.