9H30

VHL:ElonginC:ElonginB-PROTAC4 complex

This is a non-PDB format compatible entry.

Summary for 9H30

• Entry DOI: 10.2210/pdb9h30/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-C, Elongin-B, ... (5 entities in total)
• Functional Keywords: protein complex, ubiquitin ligase, ligase, protac, tubulin degradation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 46503.41

Authors

Maiocchi, A.,Abel, A.-C.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (deposition date: 2024-10-15, release date: 2025-10-29, Last modification date: 2026-05-13)

• Primary citation: Maiocchi, A.,Abel, A.C.,Basellini, M.,Perez-Pena, H.,Boiarska, Z.,Ferrandi, E.E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Passarella, D.,Prota, A.E.; Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras; Biorxiv, 2025; DOI: 10.1101/2025.05.22.655572

Experimental method

X-RAY DIFFRACTION (2.5 Å)