9H30

VHL:ElonginC:ElonginB-PROTAC4 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	von Hippel-Lindau disease tumor suppressor	polymer	197	22503.5	1	UniProt (P40337)	Homo sapiens (human)	Protein G7,pVHL
2	B (C)	Elongin-C	polymer	97	10974.6	1	UniProt (Q15369)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C (D)	Elongin-B	polymer	104	11748.4	1	UniProt (Q15370)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
4	D (B)	N-[5-(1-{2-[4-({[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}carbonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)pentanoyl]-3-methyl-D-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide	non-polymer		1276.9	1	Chemie (A1ISE)
5	E, F, G (B, C, D)	water	water		18.0	25	Chemie (HOH)

Sequence modifications

B: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 17	-	initiating methionine
Asn 18	-	expression tag
Thr 19	-	expression tag
Ile 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
Asn 27	-	expression tag
Thr 28	-	expression tag
Ser 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
Gly 32	-	expression tag
Gly 33	-	expression tag
Gly 34	-	expression tag
Gly 35	-	expression tag
Gly 36	-	expression tag
Arg 37	-	expression tag
Leu 38	-	expression tag
Val 39	-	expression tag
Pro 40	-	expression tag
Arg 41	-	expression tag
Gly 42	-	expression tag
Ser 43	-	expression tag
Met 44	-	expression tag
Ser 45	-	expression tag
Glu 46	-	expression tag
Asn 47	-	expression tag
Leu 48	-	expression tag
Tyr 49	-	expression tag
Phe 50	-	expression tag
Gln 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag

C: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	45226.5
Non-Polymers*	Number of molecules	1
	Total formula weight	1276.9
All*	Total formula weight	46503.4

*Water molecules are not included.