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9H33

T2R-TTL-PROTAC2 complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Tubulin alpha-1B chainpolymer45150204.42UniProt (P81947)Bos taurus (domestic cattle)Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2B, D
(B, D)
Tubulin beta-2B chainpolymer44549999.92UniProt (Q6B856)Bos taurus (domestic cattle)
3E
(E)
Stathmin-4polymer14216787.11UniProt (P63043)Rattus norvegicus (Norway rat)Stathmin-like protein B3,RB3
4F
(F)
Tubulin--tyrosine ligasepolymer38444378.51UniProt (A0A8V0Z8P0)Gallus gallus (chicken)
5G, P
(A, C)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.22Chemie (GTP)
6H, L, Q, T, W
(A, B, C, D, F)
MAGNESIUM IONnon-polymer24.35Chemie (MG)
7I, J, M, R
(A, B, C)
CALCIUM IONnon-polymer40.14Chemie (CA)
8K, S
(B, D)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.22Chemie (GDP)
9N
(B)
2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.21Chemie (MES)
10O
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
11U
(D)
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 5-{1-[6-({(4R)-2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,4-dihydro-1H-isoindol-4-yl}amino)-6-oxohexyl]-1H-1,2,3-triazol-4-yl}pentanoatenon-polymer1071.61Chemie (A1ISC)
12V
(F)
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERnon-polymer505.21Chemie (ACP)
13AA, BA, CA, X, Y...
(D, E, F, A, B...)
waterwater18.0273Chemie (HOH)
Sequence modifications
E: 5 - 145 (UniProt: P63043)
PDBExternal DatabaseDetails
Met 3-initiating methionine
Ala 4-expression tag
-Gly 75deletion
F: 1 - 378 (UniProt: A0A8V0Z8P0)
PDBExternal DatabaseDetails
-Ala 53deletion
-Glu 54deletion
-Met 55deletion
-Gln 56deletion
-Gln 57deletion
-Gln 58deletion
-Leu 59deletion
-Leu 60deletion
-Glu 61deletion
-Gly 62deletion
-Asp 63deletion
-Gln 64deletion
-Thr 65deletion
-Leu 66deletion
-Val 67deletion
-Leu 68deletion
-Ala 69deletion
-Ser 70deletion
-Ser 71deletion
-Thr 72deletion
-His 73deletion
-Pro 74deletion
-Glu 75deletion
-Ser 76deletion
-Val 77deletion
-Asp 78deletion
-Ser 79deletion
-Asp 80deletion
-Lys 81deletion
-Asn 82deletion
-His 83deletion
-Gly 84deletion
-Phe 85deletion
His 379-expression tag
His 380-expression tag
His 381-expression tag
His 382-expression tag
His 383-expression tag
His 384-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight261574.3
Non-Polymers*Number of molecules17
Total formula weight4078.7
All*Total formula weight265653.0
*Water molecules are not included.

243911

PDB entries from 2025-10-29

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