9H32

T2R-TTL-PROTAC3 complex

This is a non-PDB format compatible entry.

Summary for 9H32

• Entry DOI: 10.2210/pdb9h32/pdb
• Related: 9H30 9H31
• Descriptor: Tubulin alpha-1B chain, (1S,2R,3S,5S,6S,16E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16-tetraen-6-yl 4-(2-{4-[4-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-4-oxobutyl]-1H-1,2,3-triazol-1-yl}ethyl)benzoate, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265639.98

Authors

Maiocchi, A.,Abel, A.-C.,Boiarska, Z.,Steinmetz, M.O.,Passarella, D.,Prota, A.E. (deposition date: 2024-10-15, release date: 2025-10-29, Last modification date: 2026-05-13)

• Primary citation: Maiocchi, A.,Abel, A.C.,Basellini, M.,Perez-Pena, H.,Boiarska, Z.,Ferrandi, E.E.,Kozicka, Z.,Fasano, V.,Pieraccini, S.,Cappelletti, G.,Steinmetz, M.O.,Passarella, D.,Prota, A.E.; Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras; Biorxiv, 2025; DOI: 10.1101/2025.05.22.655572

Experimental method

X-RAY DIFFRACTION (2.31 Å)