9GY0

Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA

Summary for 9GY0

• Entry DOI: 10.2210/pdb9gy0/pdb
• Related: 9EO1 9EOA
• EMDB information: 51680
• Descriptor: Fanconi-associated nuclease 1, DNA (Continuous), DNA (Pre-Nick), ... (6 entities in total)
• Functional Keywords: fan1 r507h, pcna, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 228922.47

Authors

Jeyasankar, G.,Salerno-Kochan, A.,Thomsen, M. (deposition date: 2024-10-01, release date: 2025-01-29)

• Primary citation: Aretz, J.,Jeyasankar, G.,Salerno-Kochan, A.,Thomsen, M.,Thieulin-Pardo, G.,Haque, T.,Monteagudo, E.,Felsenfeld, D.,Finley, M.,Vogt, T.F.,Boudet, J.,Prasad, B.C.; A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA; Biorxiv, 2024; DOI: 10.1101/2024.10.09.617442

Experimental method

ELECTRON MICROSCOPY (3.42 Å)