9FCI

USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)

This is a non-PDB format compatible entry.

Summary for 9FCI

• Entry DOI: 10.2210/pdb9fci/pdb
• Related: 7ZH3 7ZH4 9FCJ
• EMDB information: 50316
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, Polyubiquitin-C, ZINC ION, ... (4 entities in total)
• Functional Keywords: inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 97865.34

Authors

Rennie, M.L.,Gundogdu, M.,Walden, H. (deposition date: 2024-05-15, release date: 2024-09-04)

• Primary citation: Rennie, M.L.,Gundogdu, M.,Arkinson, C.,Liness, S.,Frame, S.,Walden, H.; Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.; J.Med.Chem., 2024; PubMed: 39190802; DOI: 10.1021/acs.jmedchem.4c01184

Experimental method

ELECTRON MICROSCOPY (3.2 Å)