9FAX

CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state

Summary for 9FAX

Entry DOI	10.2210/pdb9fax/pdb
EMDB information	50285
Descriptor	Isoform 2 of Gamma-aminobutyric acid receptor subunit gamma-2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (18 entities in total)
Functional Keywords	gaba, neurotransmission, ternary complex, inhibitory synapse, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	367084.11
Authors	Kasaragod, V.B.,Aricescu, A.R. (deposition date: 2024-05-10, release date: 2025-07-02)
Primary citation	Kasaragod, V.B.,Aricescu, A.R. CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation