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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9FAX

CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007165biological_processsignal transduction
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007268biological_processchemical synaptic transmission
A0009986cellular_componentcell surface
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032229biological_processnegative regulation of synaptic transmission, GABAergic
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042802molecular_functionidentical protein binding
A0043197cellular_componentdendritic spine
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048666biological_processneuron development
A0051932biological_processsynaptic transmission, GABAergic
A0060021biological_processroof of mouth development
A0060080biological_processinhibitory postsynaptic potential
A0060119biological_processinner ear receptor cell development
A0060384biological_processinnervation
A0071420biological_processcellular response to histamine
A0090102biological_processcochlea development
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A0160001biological_processextrasynaptic signaling via GABA
A1902476biological_processchloride transmembrane transport
A1902711cellular_componentGABA-A receptor complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904862biological_processinhibitory synapse assembly
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007165biological_processsignal transduction
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0007268biological_processchemical synaptic transmission
B0009986cellular_componentcell surface
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032229biological_processnegative regulation of synaptic transmission, GABAergic
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0042802molecular_functionidentical protein binding
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048666biological_processneuron development
B0051932biological_processsynaptic transmission, GABAergic
B0060021biological_processroof of mouth development
B0060080biological_processinhibitory postsynaptic potential
B0060119biological_processinner ear receptor cell development
B0060384biological_processinnervation
B0071420biological_processcellular response to histamine
B0090102biological_processcochlea development
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B0160001biological_processextrasynaptic signaling via GABA
B1902476biological_processchloride transmembrane transport
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004890molecular_functionGABA-A receptor activity
C0005254molecular_functionchloride channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0008503molecular_functionbenzodiazepine receptor activity
C0022851molecular_functionGABA-gated chloride ion channel activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0032229biological_processnegative regulation of synaptic transmission, GABAergic
C0032590cellular_componentdendrite membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034707cellular_componentchloride channel complex
C0045211cellular_componentpostsynaptic membrane
C0051932biological_processsynaptic transmission, GABAergic
C0060078biological_processregulation of postsynaptic membrane potential
C0071420biological_processcellular response to histamine
C0098794cellular_componentpostsynapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C0160001biological_processextrasynaptic signaling via GABA
C1902476biological_processchloride transmembrane transport
C1902711cellular_componentGABA-A receptor complex
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1904862biological_processinhibitory synapse assembly
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007165biological_processsignal transduction
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0007268biological_processchemical synaptic transmission
D0009986cellular_componentcell surface
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032229biological_processnegative regulation of synaptic transmission, GABAergic
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0042802molecular_functionidentical protein binding
D0043197cellular_componentdendritic spine
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0048666biological_processneuron development
D0051932biological_processsynaptic transmission, GABAergic
D0060021biological_processroof of mouth development
D0060080biological_processinhibitory postsynaptic potential
D0060119biological_processinner ear receptor cell development
D0060384biological_processinnervation
D0071420biological_processcellular response to histamine
D0090102biological_processcochlea development
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D0160001biological_processextrasynaptic signaling via GABA
D1902476biological_processchloride transmembrane transport
D1902711cellular_componentGABA-A receptor complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1904862biological_processinhibitory synapse assembly
E0004890molecular_functionGABA-A receptor activity
E0005254molecular_functionchloride channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0008503molecular_functionbenzodiazepine receptor activity
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032229biological_processnegative regulation of synaptic transmission, GABAergic
E0032590cellular_componentdendrite membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0045211cellular_componentpostsynaptic membrane
E0051932biological_processsynaptic transmission, GABAergic
E0060078biological_processregulation of postsynaptic membrane potential
E0071420biological_processcellular response to histamine
E0098794cellular_componentpostsynapse
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E0160001biological_processextrasynaptic signaling via GABA
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
BCYS136-CYS150
ECYS151-CYS165
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues126
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues10
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues22
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsRegion: {"description":"Interaction with GABARAP","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues200
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsRegion: {"description":"Required for interaction with LHFPL4","evidences":[{"source":"UniProtKB","id":"Q69ZK9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues255
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues9
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues33
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues9
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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