9EPO

High resolution structure of FZD7 in inactive conformation

Summary for 9EPO

• Entry DOI: 10.2210/pdb9epo/pdb
• EMDB information: 19881
• Descriptor: Frizzled-7, CHOLESTEROL HEMISUCCINATE, PALMITIC ACID, ... (4 entities in total)
• Functional Keywords: gpcpr, frizzled, fzd7, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 137381.47

Authors

Bous, J.,Kinsolving, J.,Gratz, L.,Scharf, M.M.,Voss, J.,Selcuk, B.,Adebali, O.,Schulte, G. (deposition date: 2024-03-19, release date: 2024-10-02, Last modification date: 2024-10-23)

• Primary citation: Bous, J.,Kinsolving, J.,Gratz, L.,Scharf, M.M.,Voss, J.,Selcuk, B.,Adebali, O.,Schulte, G.; high-resolution structural characterization of FZD7 unravels the importance of water network and cholesterol for class F GPCRs dynamic and activation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (1.9 Å)