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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9EPO

High resolution structure of FZD7 in inactive conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0005109molecular_functionfrizzled binding
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0010008cellular_componentendosome membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0017147molecular_functionWnt-protein binding
A0019827biological_processstem cell population maintenance
A0030165molecular_functionPDZ domain binding
A0030182biological_processneuron differentiation
A0035567biological_processnon-canonical Wnt signaling pathway
A0042327biological_processpositive regulation of phosphorylation
A0042666biological_processnegative regulation of ectodermal cell fate specification
A0042813molecular_functionWnt receptor activity
A0043410biological_processpositive regulation of MAPK cascade
A0045893biological_processpositive regulation of DNA-templated transcription
A0046330biological_processpositive regulation of JNK cascade
A0055038cellular_componentrecycling endosome membrane
A0060054biological_processpositive regulation of epithelial cell proliferation involved in wound healing
A0060070biological_processcanonical Wnt signaling pathway
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060231biological_processmesenchymal to epithelial transition
A0060828biological_processregulation of canonical Wnt signaling pathway
A0071300biological_processcellular response to retinoic acid
A2000726biological_processnegative regulation of cardiac muscle cell differentiation
D0004888molecular_functiontransmembrane signaling receptor activity
D0004930molecular_functionG protein-coupled receptor activity
D0005109molecular_functionfrizzled binding
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005886cellular_componentplasma membrane
D0006355biological_processregulation of DNA-templated transcription
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0007186biological_processG protein-coupled receptor signaling pathway
D0010008cellular_componentendosome membrane
D0010812biological_processnegative regulation of cell-substrate adhesion
D0016020cellular_componentmembrane
D0016055biological_processWnt signaling pathway
D0017147molecular_functionWnt-protein binding
D0019827biological_processstem cell population maintenance
D0030165molecular_functionPDZ domain binding
D0030182biological_processneuron differentiation
D0035567biological_processnon-canonical Wnt signaling pathway
D0042327biological_processpositive regulation of phosphorylation
D0042666biological_processnegative regulation of ectodermal cell fate specification
D0042813molecular_functionWnt receptor activity
D0043410biological_processpositive regulation of MAPK cascade
D0045893biological_processpositive regulation of DNA-templated transcription
D0046330biological_processpositive regulation of JNK cascade
D0055038cellular_componentrecycling endosome membrane
D0060054biological_processpositive regulation of epithelial cell proliferation involved in wound healing
D0060070biological_processcanonical Wnt signaling pathway
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060231biological_processmesenchymal to epithelial transition
D0060828biological_processregulation of canonical Wnt signaling pathway
D0071300biological_processcellular response to retinoic acid
D2000726biological_processnegative regulation of cardiac muscle cell differentiation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues62
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues168
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsMotif: {"description":"Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-01-14

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