9EP8
Crystal structure of ROCK2 in complex with a 8-(azaindolyl)-benzoazepinone inhibitor
This is a non-PDB format compatible entry.
Summary for 9EP8
Entry DOI | 10.2210/pdb9ep8/pdb |
Descriptor | Rho-associated protein kinase 2, 8-(azaindolyl)-benzoazepinone, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | rock2, kinase inhibitor, 8-(azaindolyl)-benzoazepinone, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 185076.23 |
Authors | Pala, D.,Clark, D.,Pioselli, B.,Accetta, A.,Rancati, F. (deposition date: 2024-03-18, release date: 2024-09-25) |
Primary citation | Pala, D.,Clark, D.,Edwards, C.,Pasqua, E.,Tigli, L.,Pioselli, B.,Malysa, P.,Facchinetti, F.,Rancati, F.,Accetta, A. Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors Rsc Med Chem, 2024 Cited by DOI: 10.1039/D4MD00313FPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.63 Å) |
Structure validation
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