9EP8
Crystal structure of ROCK2 in complex with a 8-(azaindolyl)-benzoazepinone inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Rho-associated protein kinase 2 | polymer | 402 | 45900.1 | 4 | UniProt (O75116) Pfam (PF00069) | Homo sapiens (human) | Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2 |
| 2 | E, F, G, H (A, B, C, D) | 8-(azaindolyl)-benzoazepinone | non-polymer | 353.4 | 4 | Chemie (A1H6L) | |||
| 3 | I (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 19 - 417 (UniProt: O75116)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 18 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 183600.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1475.7 | |
| All* | Total formula weight | 185076.2 |
