9EP8
Crystal structure of ROCK2 in complex with a 8-(azaindolyl)-benzoazepinone inhibitor
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGAFGEVQlVrhkasqkv..........YAMK |
| Chain | Residue | Details |
| A | ILE98-LYS121 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiHrDVKpdNMLL |
| Chain | Residue | Details |
| A | LEU210-LEU222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP214 | |
| B | ASP214 | |
| C | ASP214 | |
| D | ASP214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE98 | |
| A | LYS121 | |
| B | ILE98 | |
| B | LYS121 | |
| C | ILE98 | |
| C | LYS121 | |
| D | ILE98 | |
| D | LYS121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by ROCK2 => ECO:0000250|UniProtKB:Q62868 |
| Chain | Residue | Details |
| A | THR414 | |
| B | THR414 | |
| C | THR414 | |
| D | THR414 |
