9ECK

Estrogen receptor alpha

This is a non-PDB format compatible entry.

Summary for 9ECK

• Entry DOI: 10.2210/pdb9eck/pdb
• Descriptor: Estrogen receptor, (2E)-3-{4-[(1R,3R)-2-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]-3,5-difluorophenyl}prop-2-enoic acid (2 entities in total)
• Functional Keywords: inhibitor, complex, estrogen receptor alpha, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 119748.29

Authors

Lee, C.C. (deposition date: 2024-11-14, release date: 2026-06-24)

• Primary citation: Hegde, S.,Zhang, G.,Huang, P.,Bunker, K.; Human Estrogen Receptor Ligand-Binding Domain Complexed with an Orally Bioavailable, Potent and Selective Degrader.; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.2 Å)