9ECK

Estrogen receptor alpha

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Estrogen receptor	polymer	259	29502.6	4	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	E, F, G, H (A, B, C, D)	(2E)-3-{4-[(1R,3R)-2-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]-3,5-difluorophenyl}prop-2-enoic acid	non-polymer		434.5	4	Chemie (A1BHJ)

Sequence modifications

A, B, C, D: 298 - 553 (UniProt: P03372)

PDB	External Database	Details
Ser 295	-	expression tag
Asn 296	-	expression tag
Ala 297	-	expression tag
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	118010.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1737.9
All*	Total formula weight	119748.3

*Water molecules are not included.