9DOD

Crystal structure of PRMT5:MEP50 in complex with PRT543

This is a non-PDB format compatible entry.

Summary for 9DOD

• Entry DOI: 10.2210/pdb9dod/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein WDR77, 7-[(3xi,5R)-5-C-(3,4-dichlorophenyl)-3-C-methyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (5 entities in total)
• Functional Keywords: prmt5, mep50, inhibitor, protein-ligand complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 109935.05

Authors

Leal, R.A.,Pitis, P.M.,Dou, Y.,Lin, H.,Wang, M.,Xu, C. (deposition date: 2024-09-18, release date: 2025-02-12, Last modification date: 2025-03-19)

Primary citation

Bewersdorf, J.P.,Mi, X.,Lu, B.,Kuykendall, A.,Sallman, D.,Patel, M.,Stevens, D.,Philipovskiy, A.,Sutamtewagul, G.,Masarova, L.,Keiffer, G.,Verma, A.,Bhagwat, N.,Wang, M.,Moore, A.,Rager, J.,Heiser, D.,Ro, S.,Hong, W.J.,Abdel-Wahab, O.,Stein, E.M.
Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies.
Leukemia, 39:765-769, 2025

PubMed Abstract: [Image: see text]

PubMed: 39856223
DOI: 10.1038/s41375-025-02515-8

Experimental method

X-RAY DIFFRACTION (2.5 Å)