9C7A

Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant

Summary for 9C7A

• Entry DOI: 10.2210/pdb9c7a/pdb
• Descriptor: Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... (5 entities in total)
• Functional Keywords: protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna complex, rna binding protein-splicing complex, rna binding protein, rna binding protein-rna-dna complex, rna binding protein/rna/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 24853.72

Authors

Maji, D.,Jenkins, J.L.,Kielkopf, C.L. (deposition date: 2024-06-10, release date: 2024-10-02)

• Primary citation: Maji, D.,Jenkins, J.L.,Boutz, P.L.,Kielkopf, C.L.; Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)