9C50

Replacement of a single residue changes the primary specificity of thrombin

9C50 の概要

• エントリーDOI: 10.2210/pdb9c50/pdb
• 分子名称: Thrombin A-chain, Thrombin B-chain, FPF, ... (5 entities in total)
• 機能のキーワード: coagulation, thrombin, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 71973.01

構造登録者

Dei Rossi, A.,Deavila, S.,Mohammed, B.M.,Korolev, S.,Di Cera, E. (登録日: 2024-06-05, 公開日: 2025-01-22, 最終更新日: 2025-04-16)

主引用文献

Dei Rossi, A.,Deavila, S.,Mohammed, B.M.,Korolev, S.,Di Cera, E.
Replacement of a single residue changes the primary specificity of thrombin.
J.Thromb.Haemost., 23:1241-1246, 2025

PubMed Abstract: Thrombin prefers substrates carrying Arg at the site of cleavage (P1) because of the presence of D189 in the primary specificity (S1) pocket but can also cleave substrates carrying Phe at P1. The structural basis of this property is unknown.

PubMed: 39756655
DOI: 10.1016/j.jtha.2024.12.024

実験手法

X-RAY DIFFRACTION (2.5 Å)