9C2C

Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state

This is a non-PDB format compatible entry.

Summary for 9C2C

• Entry DOI: 10.2210/pdb9c2c/pdb
• Related: 9C2A 9C2B
• EMDB information: 45152 45153 45154
• Descriptor: P2X purinoceptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid) (3 entities in total)
• Functional Keywords: membrane protein, ion channel, ligand-gated ion channel, p2x receptor, allosteric antagonist
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 145083.16

Authors

Oken, A.C.,Lisi, N.E.,Ditter, I.A.,Shi, H.,Mansoor, S.E. (deposition date: 2024-05-30, release date: 2024-10-09)

• Primary citation: Oken, A.C.,Lisi, N.E.,Ditter, I.A.,Shi, H.,Nechiporuk, N.A.,Mansoor, S.E.; Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding.; Nat Commun, 15:8490-8490, 2024; PubMed: 39353889; DOI: 10.1038/s41467-024-52636-4

Experimental method

ELECTRON MICROSCOPY (2.9 Å)