9B7B

Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA01:01/HLA-DRB104:01)

Summary for 9B7B

Entry DOI	10.2210/pdb9b7b/pdb
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, Hemagglutinin HA1 chain, HLA class II histocompatibility antigen DR beta chain, h44H10-V22 Antibody, heavy chain, ... (6 entities in total)
Functional Keywords	antibody, humanized, mhc class ii, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	191261.77
Authors	Kassardjian, A.,Julien, J.P. (deposition date: 2024-03-27, release date: 2024-08-07)
Primary citation	Kassardjian, A.,Ivanochko, D.,Barber, B.,Jetha, A.,Julien, J.P. Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework. Antibodies, 13:-, 2024 Cited by PubMed: 39051333 DOI: 10.3390/antib13030057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.08 Å)

Structure validation