9B7B
Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 190 | 22124.9 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, F (B, F) | Hemagglutinin HA1 chain, HLA class II histocompatibility antigen DR beta chain | polymer | 226 | 25935.8 | 2 | Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (A0A1V1IGJ9) | Homo sapiens (human) | |
| 3 | C, G (C, G) | h44H10-V22 Antibody, heavy chain | polymer | 223 | 23537.5 | 2 | Homo sapiens | ||
| 4 | D, H (D, H) | h44H10-V22 Antibody, light chain | polymer | 214 | 23494.2 | 2 | Homo sapiens | ||
| 5 | I, J, L, M (A, B, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | K, N (D, H) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A, E: 1 - 181 (UniProt: P01903)
| PDB | External Database | Details |
|---|---|---|
| Thr 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Glu 185 | - | expression tag |
| Asn 186 | - | expression tag |
| Leu 187 | - | expression tag |
| Tyr 188 | - | expression tag |
| Phe 189 | - | expression tag |
| Gln 190 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 190184.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1077.0 | |
| All* | Total formula weight | 191261.8 |
