8ZWG

cryoEM structure of JR14a bound C3aR-Gi complex

This is a non-PDB format compatible entry.

Summary for 8ZWG

• Entry DOI: 10.2210/pdb8zwg/pdb
• Related: 8ZWF
• EMDB information: 60526
• Descriptor: Beta-2 adrenergic receptor,C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: complement receptor, c3ar, non-peptide agonist, jr14a, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 176537.37

Authors

Luo, P.,Xu, Y.,Xu, H.E. (deposition date: 2024-06-13, release date: 2025-05-14)

• Primary citation: Luo, P.,Xin, W.,Guo, S.,Li, X.,Zhang, Q.,Xu, Y.,He, X.,Wang, Y.,Fan, W.,Yuan, Q.,Wu, K.,Hu, W.,Zhuang, Y.,Xu, H.E.,Xie, X.; Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR.; Cell Discov, 11:7-7, 2025; PubMed: 39788969; DOI: 10.1038/s41421-024-00765-x

Experimental method

ELECTRON MICROSCOPY (2.87 Å)