8ZWF

cryoEM structure of JR14a bound C3aR-BRIL-BAG2 complex

This is a non-PDB format compatible entry.

Summary for 8ZWF

• Entry DOI: 10.2210/pdb8zwf/pdb
• EMDB information: 60525
• Descriptor: Beta-2 adrenergic receptor,C3a anaphylatoxin chemotactic receptor,Soluble cytochrome b562, anti-BRIL Fab LC, anti-BRIL Fab HC, ... (4 entities in total)
• Functional Keywords: complement receptor, c3ar, non-peptide agonist, jr14a, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 123023.23

Authors

Luo, P.,Xu, Y.,Xu, H.E. (deposition date: 2024-06-13, release date: 2025-05-14)

• Primary citation: Luo, P.,Xin, W.,Guo, S.,Li, X.,Zhang, Q.,Xu, Y.,He, X.,Wang, Y.,Fan, W.,Yuan, Q.,Wu, K.,Hu, W.,Zhuang, Y.,Xu, H.E.,Xie, X.; Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR.; Cell Discov, 11:7-7, 2025; PubMed: 39788969; DOI: 10.1038/s41421-024-00765-x

Experimental method

ELECTRON MICROSCOPY (3 Å)