8ZWF
cryoEM structure of JR14a bound C3aR-BRIL-BAG2 complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-2 adrenergic receptor,C3a anaphylatoxin chemotactic receptor,Soluble cytochrome b562 | polymer | 646 | 72253.0 | 1 | UniProt (P07550) UniProt (Q16581) UniProt (P0ABE7) Pfam (PF00001) | Homo sapiens (human) | Beta-2 adrenoreceptor,Beta-2 adrenoceptor,C3AR,C3a-R,Cytochrome b-562 |
| 2 | B (C) | anti-BRIL Fab LC | polymer | 235 | 25915.7 | 1 | Homo sapiens | ||
| 3 | C (D) | anti-BRIL Fab HC | polymer | 229 | 24321.1 | 1 | Homo sapiens | ||
| 4 | D (A) | (2~{S})-5-[bis(azanyl)methylideneamino]-2-[[5-[bis(4-chlorophenyl)methyl]-3-methyl-thiophen-2-yl]carbonylamino]pentanoic acid | non-polymer | 533.5 | 1 | Chemie (A1D9A) |
Sequence modifications
A: -38 - -9 (UniProt: P07550)
A: 1 - 362 (UniProt: Q16581)
A: 368 - 472 (UniProt: P0ABE7)
A: 481 - 590 (UniProt: Q16581)
| PDB | External Database | Details |
|---|---|---|
| Asp -47 | - | expression tag |
| Tyr -46 | - | expression tag |
| Lys -45 | - | expression tag |
| Asp -44 | - | expression tag |
| Asp -43 | - | expression tag |
| Asp -42 | - | expression tag |
| Asp -41 | - | expression tag |
| Val -40 | - | expression tag |
| Asp -39 | - | expression tag |
| Gln -12 | Glu 27 | engineered mutation |
| Glu -8 | - | linker |
| Asn -7 | - | linker |
| Leu -6 | - | linker |
| Tyr -5 | - | linker |
| Phe -4 | - | linker |
| Gln -3 | - | linker |
| Gly -2 | - | linker |
| Ala -1 | - | linker |
| Ser 0 | - | linker |
A: 368 - 472 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 374 | Met 29 | engineered mutation |
| Ile 469 | His 124 | engineered mutation |
| Leu 473 | - | linker |
| Glu 474 | - | linker |
| Arg 475 | - | linker |
| Ala 476 | - | linker |
| Arg 477 | - | linker |
| Ser 478 | - | linker |
| Thr 479 | - | linker |
| Leu 480 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 363 | - | linker |
| Arg 364 | - | linker |
| Arg 365 | - | linker |
| Gln 366 | - | linker |
| Leu 367 | - | linker |
| His 591 | - | expression tag |
| His 592 | - | expression tag |
| His 593 | - | expression tag |
| His 594 | - | expression tag |
| His 595 | - | expression tag |
| His 596 | - | expression tag |
| His 597 | - | expression tag |
| His 598 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 122489.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 533.5 | |
| All* | Total formula weight | 123023.2 |
