8ZCA

Crystal structure of human CD47 ECD bound to Fab of Hu1C8

Summary for 8ZCA

Entry DOI	10.2210/pdb8zca/pdb
Descriptor	1C8 Fab light chain, 1C8 Fab heavy chain, Leukocyte surface antigen CD47, ... (7 entities in total)
Functional Keywords	cd47, antibody, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	126122.35
Authors	Chen, Z.,Ding, J. (deposition date: 2024-04-29, release date: 2025-05-07)
Primary citation	Lu, X.,Sun, B. The humanized antibody Hu1C8 binds to a distinct epitope of CD47 in a novel metal ion-dependent manner to induce low RBC toxicity and effective antitumour activity To Be Published,
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation