8ZCA

Crystal structure of human CD47 ECD bound to Fab of Hu1C8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	1C8 Fab light chain	polymer	218	23801.3	2		Homo sapiens (human)
2	B, D (D, C)	1C8 Fab heavy chain	polymer	225	23760.6	2		Homo sapiens (human)
3	E, F (E, F)	Leukocyte surface antigen CD47	polymer	131	14924.7	2	UniProt (Q08722) Pfam (PF08204)	Homo sapiens (human)	Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6
4	G, I (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	H, J (D, C)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	K, L, M, N (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	O, P, Q, R, S... (A, D, B, C, E...)	water	water		18.0	170	Chemie (HOH)

Sequence modifications

E, F: 1 - 121 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	conflict
Gly 122	-	expression tag
Ser 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124973.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1149.2
All*	Total formula weight	126122.4

*Water molecules are not included.