8ZBR

Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (apo-form)

Summary for 8ZBR

• Entry DOI: 10.2210/pdb8zbr/pdb
• EMDB information: 39908
• Descriptor: ATP-binding cassette sub-family C member 4, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE (3 entities in total)
• Functional Keywords: atp-binding cassette sub-family c member 4, multidrug resistance proteins (mrps), multidrug-resistance (mdr), transport protein, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 155310.41

Authors

Xie, Z.,Long, F. (deposition date: 2024-04-27, release date: 2025-04-09)

• Primary citation: Xie, Z.,Long, F.; Structural insights into the human MRP4 mediating multiple drug resistance (MDR) to vincristine and 5-FU and reversal of MDR by lapatinib; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.92 Å)