8ZBR

Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (apo-form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001409	molecular_function	guanine nucleotide transmembrane transporter activity
A	0002576	biological_process	platelet degranulation
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006855	biological_process	xenobiotic transmembrane transport
A	0006869	biological_process	lipid transport
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0015132	molecular_function	prostaglandin transmembrane transporter activity
A	0015143	molecular_function	urate transmembrane transporter activity
A	0015216	molecular_function	purine nucleotide transmembrane transporter activity
A	0015431	molecular_function	ABC-type glutathione S-conjugate transporter activity
A	0015432	molecular_function	ABC-type bile acid transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015732	biological_process	prostaglandin transport
A	0015747	biological_process	urate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016404	molecular_function	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0031088	cellular_component	platelet dense granule membrane
A	0032310	biological_process	prostaglandin secretion
A	0034634	molecular_function	glutathione transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0060271	biological_process	cilium assembly
A	0070730	biological_process	cAMP transport
A	0071716	biological_process	leukotriene transport
A	0098591	cellular_component	external side of apical plasma membrane
A	0140115	biological_process	export across plasma membrane
A	0140359	molecular_function	ABC-type transporter activity
A	0150104	biological_process	transport across blood-brain barrier
A	1903790	biological_process	guanine nucleotide transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARVNLARAV

Chain	Residue	Details
A	LEU535-VAL549
A	PHE1177-ILE1191

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	167
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	31
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	284
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	233
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	19
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A0AAA9T569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38886124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8XOM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ZBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40138312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ZBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---