8YQO

Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ

This is a non-PDB format compatible entry.

Summary for 8YQO

• Entry DOI: 10.2210/pdb8yqo/pdb
• EMDB information: 39501
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (~{E})-2-(2,5-dimethoxyphenyl)-~{N}-[2-(4-hydroxyphenyl)ethyl]-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide (3 entities in total)
• Functional Keywords: cyp51a1;flz;cryo-em;parkinson's disease;alzheimer's disease, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53536.17

Authors

Zhou, L.C. (deposition date: 2024-03-19, release date: 2025-03-26, Last modification date: 2025-07-16)

• Primary citation: Zhou, L.C.; Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.52 Å)