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Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lanosterol 14-alpha demethylase | polymer | 458 | 52470.2 | 1 | UniProt (Q16850) Pfam (PF00067) | Homo sapiens (human) | LDM,CYPLI,Cytochrome P450 51A1,CYP51A1,Cytochrome P450-14DM,Cytochrome P45014DM,Cytochrome P450LI,Sterol 14-alpha demethylase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | (~{E})-2-(2,5-dimethoxyphenyl)-~{N}-[2-(4-hydroxyphenyl)ethyl]-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide | non-polymer | 449.5 | 1 | Chemie (A1D61) |
Sequence modifications
A: 61 - 503 (UniProt: Q16850)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | initiating methionine |
| Ala 51 | - | expression tag |
| Lys 52 | - | expression tag |
| Lys 53 | - | expression tag |
| Thr 54 | - | expression tag |
| Ser 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Lys 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Lys 59 | - | expression tag |
| Leu 60 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52470.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1066.0 | |
| All* | Total formula weight | 53536.2 |
