8XJZ

Cryo-EM structure of colibactin assembly line polyketide synthase ClbI KS-AT didomain crosslinked with its precursor module, ClbH

Summary for 8XJZ

Entry DOI	10.2210/pdb8xjz/pdb
Related	8XBL 8XJT 8XJU 8XJY
EMDB information	38411
Descriptor	Polyketide synthase, Peptide synthetase, polypeptide from ClbH (3 entities in total)
Functional Keywords	colibactin, microbiome, polyketide synthase, colorectal cancer, nrps-pks hybrid, biosynthetic protein, transferase
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	381263.96
Authors	Kim, M.,Kim, J.,Kang, J.Y. (deposition date: 2023-12-22, release date: 2025-05-21)
Primary citation	Kim, M.,Kim, J.,Olinares, P.D.B.,Park, J.,Chait, B.T.,Kang, J.Y. Cryo-EM structures of human microbiome-derived polyketide synthases that assemble genotoxic colibactin Structure, 33:1-16, 2025 Cited by DOI: 10.1016/j.str.2025.04.017 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.67 Å)

Structure validation