8XFD

Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)

Summary for 8XFD

Entry DOI	10.2210/pdb8xfd/pdb
Descriptor	Isoform L-type of Pyruvate kinase PKLR, MAGNESIUM ION, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (5 entities in total)
Functional Keywords	pyruvate kinase, allosteric activator, mitapivat, ag-348, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	236615.43
Authors	Sun, R.,Achour, A. (deposition date: 2023-12-13, release date: 2024-05-15)
Primary citation	Han, X.,Sandalova, T.,Zhang, C.,Mardinoglu, A.,Achour, A.,Sun, R. High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348 Crystals, 2024 Cited by DOI: 10.3390/cryst14050441 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation