8XFD
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform L-type of Pyruvate kinase PKLR | polymer | 543 | 58564.2 | 4 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | E, G, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | F, H, K, M (A, B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
| 4 | I, N (B, D) | mitapivat | non-polymer | 450.6 | 2 | Chemie (WV2) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 886 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 234256.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2358.8 | |
| All* | Total formula weight | 236615.4 |
