8XFD
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform L-type of Pyruvate kinase PKLR | polymer | 543 | 58564.2 | 4 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | E, G, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 3 | F, H, K, M (A, B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) PubChem (16219368) PubChem (718) PubChem (10267) PubChem (172313) PubChem (24802138) PubChem (440117) PubChem (46937007) PubChem (5702629) PubChem (89534552) PubChem (445557) PubChem (92209485) PubChem (92209486) PubChem (12800340) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 4 | I, N (B, D) | mitapivat | non-polymer | 450.6 | 2 | Chemie (WV2) PubChem (59634741) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 886 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 234256.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2358.8 | |
| All* | Total formula weight | 236615.4 |
