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8XFD

Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001666biological_processresponse to hypoxia
A0003824molecular_functioncatalytic activity
A0004743molecular_functionpyruvate kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006096biological_processglycolytic process
A0007584biological_processresponse to nutrient
A0009749biological_processresponse to glucose
A0010038biological_processresponse to metal ion
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0030955molecular_functionpotassium ion binding
A0032869biological_processcellular response to insulin stimulus
A0033198biological_processresponse to ATP
A0042866biological_processpyruvate biosynthetic process
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0051591biological_processresponse to cAMP
A0070062cellular_componentextracellular exosome
A0071872biological_processcellular response to epinephrine stimulus
B0000287molecular_functionmagnesium ion binding
B0001666biological_processresponse to hypoxia
B0003824molecular_functioncatalytic activity
B0004743molecular_functionpyruvate kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006096biological_processglycolytic process
B0007584biological_processresponse to nutrient
B0009749biological_processresponse to glucose
B0010038biological_processresponse to metal ion
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0030955molecular_functionpotassium ion binding
B0032869biological_processcellular response to insulin stimulus
B0033198biological_processresponse to ATP
B0042866biological_processpyruvate biosynthetic process
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0051591biological_processresponse to cAMP
B0070062cellular_componentextracellular exosome
B0071872biological_processcellular response to epinephrine stimulus
C0000287molecular_functionmagnesium ion binding
C0001666biological_processresponse to hypoxia
C0003824molecular_functioncatalytic activity
C0004743molecular_functionpyruvate kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006096biological_processglycolytic process
C0007584biological_processresponse to nutrient
C0009749biological_processresponse to glucose
C0010038biological_processresponse to metal ion
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0030955molecular_functionpotassium ion binding
C0032869biological_processcellular response to insulin stimulus
C0033198biological_processresponse to ATP
C0042866biological_processpyruvate biosynthetic process
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0051591biological_processresponse to cAMP
C0070062cellular_componentextracellular exosome
C0071872biological_processcellular response to epinephrine stimulus
D0000287molecular_functionmagnesium ion binding
D0001666biological_processresponse to hypoxia
D0003824molecular_functioncatalytic activity
D0004743molecular_functionpyruvate kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006096biological_processglycolytic process
D0007584biological_processresponse to nutrient
D0009749biological_processresponse to glucose
D0010038biological_processresponse to metal ion
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0030955molecular_functionpotassium ion binding
D0032869biological_processcellular response to insulin stimulus
D0033198biological_processresponse to ATP
D0042866biological_processpyruvate biosynthetic process
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0051591biological_processresponse to cAMP
D0070062cellular_componentextracellular exosome
D0071872biological_processcellular response to epinephrine stimulus
Functional Information from PROSITE/UniProt
site_idPS00110
Number of Residues13
DetailsPYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV
ChainResidueDetails
AILE275-VAL287

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB
ChainResidueDetails
AARG83
ASER87
BARG83
BSER87
CARG83
CSER87
DARG83
DSER87

site_idSWS_FT_FI2
Number of Residues48
DetailsBINDING: BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF
ChainResidueDetails
AASN85
ATRP492
AARG499
AARG526
BASN85
BASP123
BTHR124
BLYS280
BGLU282
BGLY305
BASP306
AASP123
BTHR338
BTHR442
BTRP492
BARG499
BARG526
CASN85
CASP123
CTHR124
CLYS280
CGLU282
ATHR124
CGLY305
CASP306
CTHR338
CTHR442
CTRP492
CARG499
CARG526
DASN85
DASP123
DTHR124
ALYS280
DLYS280
DGLU282
DGLY305
DASP306
DTHR338
DTHR442
DTRP492
DARG499
DARG526
AGLU282
AGLY305
AASP306
ATHR338
ATHR442

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14618
ChainResidueDetails
AARG130
ALYS217
BARG130
BLYS217
CARG130
CLYS217
DARG130
DLYS217

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250|UniProtKB:P00549
ChainResidueDetails
ALYS280
BLYS280
CLYS280
DLYS280

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
AGLU0
DGLU0
DGLU17
DGLN24
AGLU17
AGLN24
BGLU0
BGLU17
BGLN24
CGLU0
CGLU17
CGLN24

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER10
ASER259
BSER10
BSER259
CSER10
CSER259
DSER10
DSER259

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PDB entries from 2024-08-21

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