8X3S

Crystal structure of human WDR5 in complex with PTEN

8X3S の概要

• エントリーDOI: 10.2210/pdb8x3s/pdb
• 分子名称: WD repeat-containing protein 5, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (3 entities in total)
• 機能のキーワード: complex, cell proliferation, cancer, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37944.85

構造登録者

Liu, Y.,Huang, X.,Shang, X. (登録日: 2023-11-14, 公開日: 2024-05-29)

• 主引用文献: Huang, X.,Zhang, C.,Shang, X.,Chen, Y.,Xiao, Q.,Wei, Z.,Wang, G.,Zhen, X.,Xu, G.,Min, J.,Shen, S.,Liu, Y.; The NTE domain of PTEN alpha / beta promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.; Cell Death Dis, 15:335-335, 2024; PubMed: 38744853; DOI: 10.1038/s41419-024-06714-6

実験手法

X-RAY DIFFRACTION (1.87 Å)