8VHU

Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit

8VHU の概要

• エントリーDOI: 10.2210/pdb8vhu/pdb
• 関連するPDBエントリー: 8VHN 8VHO 8VHP 8VHQ 8VHR
• 分子名称: Fusion protein of Ribonucleoside-diphosphate reductase 1 subunits alpha and beta, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 183754.97

構造登録者

Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (登録日: 2024-01-02, 公開日: 2024-09-04, 最終更新日: 2024-10-09)

• 主引用文献: Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L.; How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.; Biochemistry, 63:2517-2531, 2024; PubMed: 39164005; DOI: 10.1021/acs.biochem.4c00329

実験手法

X-RAY DIFFRACTION (2.1 Å)