8VEU

Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 23

This is a non-PDB format compatible entry.

Summary for 8VEU

• Entry DOI: 10.2210/pdb8veu/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... (6 entities in total)
• Functional Keywords: mtap-null, sam, mta, mta-cooperative, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 113517.15

Authors

Whittington, D.A. (deposition date: 2023-12-20, release date: 2024-04-24, Last modification date: 2024-05-08)

• Primary citation: Cottrell, K.M.,Briggs, K.J.,Whittington, D.A.,Jahic, H.,Ali, J.A.,Davis, C.B.,Gong, S.,Gotur, D.,Gu, L.,McCarren, P.,Tonini, M.R.,Tsai, A.,Wilker, E.W.,Yuan, H.,Zhang, M.,Zhang, W.,Huang, A.,Maxwell, J.P.; Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.; J.Med.Chem., 67:6064-6080, 2024; PubMed: 38595098; DOI: 10.1021/acs.jmedchem.4c00133

Experimental method

X-RAY DIFFRACTION (2.46 Å)