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8VEU

Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 23

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProtein arginine N-methyltransferase 5polymer64573763.61UniProt (O14744)
Pfam (PF17285)
Pfam (PF05185)
Pfam (PF17286)
In PDB
Homo sapiens (human)72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
2BMethylosome protein 50polymer35037862.41UniProt (Q9BQA1)
Pfam (PF00400)
In PDB
Homo sapiens (human)MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50
3A5'-DEOXY-5'-METHYLTHIOADENOSINEnon-polymer297.31Chemie (MTA)
4AN-(6-amino-5-methylpyridin-3-yl)-2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl]-2-oxoacetamidenon-polymer352.41Chemie (A1AAT)
5A, B1,2-ETHANEDIOLnon-polymer62.120Chemie (EDO)
6waterwater18.093Chemie (HOH)
Sequence modifications
A: 2 - 637 (UniProt: O14744)
PDBExternal DatabaseDetails
Met -7-initiating methionine
Asp -6-expression tag
Tyr -5-expression tag
Lys -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Asp 0-expression tag
Lys 1-expression tag
B: 2 - 342 (UniProt: Q9BQA1)
PDBExternal DatabaseDetails
Met -7-initiating methionine
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight111626.0
Non-Polymers*Number of molecules22
Total formula weight1891.1
All*Total formula weight113517.2
*Water molecules are not included.

222624

PDB entries from 2024-07-17

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