8VD0
Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP2
Summary for 8VD0
Entry DOI | 10.2210/pdb8vd0/pdb |
Related | 8VCX 8VCY 8VD2 8VDD 8VDU |
Descriptor | MHC class II HLA-DQ-alpha chain, Hybrid insulin peptide (HIP; InsC8-15-IAPP74-80),MHC class II HLA-DQ-beta-1 chimera, T-CELL-RECEPTOR, TCR ET650-4 alpha, ... (8 entities in total) |
Functional Keywords | immune t cell receptor-pmhc ii complex, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 194132.31 |
Authors | Tran, T.M.,Lim, J.J.,Loh, T.Y.,Mannering, I.S.,Rossjohn, J.,Reid, H.H. (deposition date: 2023-12-14, release date: 2024-08-07, Last modification date: 2024-09-04) |
Primary citation | Tran, M.T.,Lim, J.J.,Loh, T.J.,Mannering, S.I.,Rossjohn, J.,Reid, H.H. A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8. J.Biol.Chem., 300:107612-107612, 2024 Cited by PubMed: 39074636DOI: 10.1016/j.jbc.2024.107612 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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