8VD0

Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, F)	MHC class II HLA-DQ-alpha chain	polymer	185	21150.6	2	UniProt (Q30069) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	DQA1*03:01 (DQ8-alpha chain
2	B, D (C, H)	Hybrid insulin peptide (HIP; InsC8-15-IAPP74-80),MHC class II HLA-DQ-beta-1 chimera	polymer	213	24450.4	2	UniProt (O19707) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)
3	E, G (D, I)	T-CELL-RECEPTOR, TCR ET650-4 alpha	polymer	206	22921.6	2		Homo sapiens (human)
4	F, H (E, J)	T-CELL-RECEPTOR, TCR ET650-4 beta	polymer	240	27153.1	2		Homo sapiens (human)
5	I, J, O, P, T (A, F, H)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	AA, CA, DA, K, L... (I, J, A, F, H...)	GLYCEROL	non-polymer		92.1	12	Chemie (GOL)
7	BA, EA, M, N, W... (I, J, A, C, D...)	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
8	FA, GA, HA, IA, JA... (A, C, F, H, D...)	water	water		18.0	374	Chemie (HOH)

Sequence modifications

A, F: -1 - 182 (UniProt: Q30069)

PDB	External Database	Details
Cys 72	Ile 75	engineered mutation

C, H: -2 - 18 (PDB: 8VD0)
C, H: 19 - 210 (UniProt: O19707)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	191351.3
Non-Polymers*	Number of molecules	23
	Total formula weight	2781.0
All*	Total formula weight	194132.3

*Water molecules are not included.